1-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-proline
fmoc-D-proline
CAS: 101555-62-8
Molecular Formula: C20H19NO4
1-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-proline - Names and Identifiers
| Name | fmoc-D-proline |
| Synonyms | Fmoc-D-Pro-OH fmoc-D-proline N-ALPHA-FMOC-D-PROLINE 9-FLUORENYLMETHOXYCARBONYL-D-PROLINE N-(9-FLUORENYLMETHOXYCARBONYL)-D-PROLINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-PROLINE 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-proline N-alpha-(9-fluorenylmethyloxycarbonyl)-D-proline N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-PROLINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-PROLINE MONOHYDRATE N-(9-FLUORENYLMETHOXYCARBONYL)-D-PYRROLIDINE-2-CARBOXYLIC ACID (R)-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-(9H-FLUOREN-9-YLMETHYL) ESTER |
| CAS | 101555-62-8 |
| EINECS | 1806241-263-5 |
| InChI | InChI=1/C20H19NO4.H2O/c22-19(23)18-10-5-11-21(18)20(24)25-12-17-15-8-3-1-6-13(15)14-7-2-4-9-16(14)17;/h1-4,6-9,17-18H,5,10-12H2,(H,22,23);1H2/t18-;/m1./s1 |
1-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-proline - Physico-chemical Properties
| Molecular Formula | C20H19NO4 |
| Molar Mass | 337.37 |
| Density | 1.328±0.06 g/cm3(Predicted) |
| Melting Point | 110-116°C |
| Boling Point | 548.6±43.0 °C(Predicted) |
| Specific Rotation(α) | 32 ° (C=1, DMF) |
| Appearance | White powder |
| Color | White to Light yellow |
| BRN | 5856698 |
| pKa | 3.95±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 32 ° (C=1, DMF) |
| MDL | MFCD00077067 |
1-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-proline - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 2933 99 80 |
1-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-proline - Reference Information
| Application | D-proline, also known as D-pyrrolidin-2-carboxylic acid, is an important chiral compound, which can be used as a resolution agent and Chiral reagents can also be used to synthesize chiral intermediates of certain chiral drugs. |
| preparation | D-proline is added into a round bottom flask, 10% sodium carbonate aqueous solution is added, stirred and dissolved, then dioxane is added, the dioxane solution of 9-fluorene methoxycarbonyl chloride is slowly added into the reaction solution under an ice bath, and then reacted in an ice bath for 2 hours after the dropout is completed, and then reacted at room temperature for 8 hours, add water to dilute, extract 4 times with ether, place the water layer in an ice bath, adjust the pH value with concentrated hydrochloric acid to show blue color on Congo red test paper, leave it overnight in the refrigerator, and extract the white precipitate with ethyl acetate, wash the combined organic liquid with water, dry the organic layer with anhydrous magnesium sulfate, and drain the product FMOC-D-proline. |
Last Update：2024-04-09 20:02:46
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